CpG oligodeoxynucleotide triggers the liver inflammatory reaction and abrogates spontaneous tolerance
نویسندگان
چکیده
منابع مشابه
Therapeutic administration of a synthetic CpG oligodeoxynucleotide triggers formation of anti-CpG antibodies.
The synthetic oligodeoxynucleotide CpG 7909, which contains unmethylated cytosine/guanine (CpG) motifs, has potent immunostimulatory effects when coadministered with NY-ESO-1 peptides or recombinant NY-ESO-1 protein, resulting in an enhanced cellular and humoral immune response against the vaccine antigen. In this study, we report the development of anti-CpG-ODN antibodies in 21 of 37 patients ...
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ژورنال
عنوان ژورنال: Liver Transplantation
سال: 2009
ISSN: 1527-6465
DOI: 10.1002/lt.21771